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Spiders hold the market for the strongest silks but are too aggressive and territorial to be farmed. The next best alternative involves incorporating spider DNA into silkworms, an expensive and difficult-to-scale process. On October 6 in the journal Matter, scientists at Tianjin University show how the silk naturally produced by silkworms can be made 70% stronger than spider silks by removing a sticky outer layer and manually spinning the silk.
"Our finding reverses the previous perception that silkworm silk cannot compete with spider silks on mechanical performance," says senior author Zhi Lin, a biochemist at Tianjin University.
Historically, silkworm silk has been used in fashion as a source of luxury robes and apparel fitting of royalty, but today, silk-based materials are more likely to be found in biomedicine as a material for stitches and surgical mesh. It's also used for tissue regeneration experiments due to its mechanical properties, biocompatibility, and biodegradability.
The most common way to acquire silk is by farming silkworms. However, these silks are not as durable and are weaker than silk spun by spiders, specifically spider dragline silks which naturally do well under high tension. "Dragline silk is the main structural silk of a spider web. It is also used as a lifeline for a spider to fall from trees," says Lin. Silkworms, on the other hand, use their softer silks for the construction of their cotton-ball-like cocoons during transformation into their moth forms.
While other groups have combined DNA from spiders to make silk, Lin's group wanted to use common silkworms, which are more accessible and easily managed. They were by inspired by the artificial spinning of spider eggcase silk, which is a close relative to silkworm silk and has been shown to do well in the spinning process.
Natural silkworm silk fiber is composed of a core fiber wrapped by silk glue, which interferes with the spinning of the fibers for commercial purposes. To get around this, the researchers boiled silk from the common silkworm Bombyx mori in a bath of chemicals that could dissolve this glue and minimize the degradation of silk proteins. Then, to enhance the silk for spinning, the research team solidified the silk in a bath of metals and sugars.
"Since silkworm silk is very structurally similar to eggcase spider silk, which has previously been demonstrated to do well in a mix of zinc and iron baths, we thought to test this alternative method to avoid hazardous conditions used elsewhere," says Lin. "Sucrose, a form of sugar, may increase the density and viscosity of the coagulation bath, which consequently affects the formation of the fibers."
Once manually spun and drawn, the silks are thinner than the original silkworm silk, reaching nearly the same size as spider silks. Upon observation under a microscope, Lin describes them as "smooth and strong," indicating that the artificial fibers could withstand force.
"We hope that this work opens up a promising way to produce profitable high-performance artificial silks," Lin says.
Financial support was provided by a startup grant from Tianjin University and National Natural Science Foundation of China.
https://www.sciencedaily.com/releases/2022/10/221006111845.htm#:~:text=Summary%3A,difficult%2Dto%2Dscale%20process
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