Biotech Values

[biotech jim]

Try this information, and please note that I am only an amateur immunologist:

NR4a1/2 deletion promotes accumulation of TCF1+ stem-like precursors of exhausted CD8+ T cells in the tumor microenvironment
Tanakorn Srirat
Taeko Hayakawa
Setsuko Mise-Omata
Shigeyuki Shichino
Minako Ito
Akihiko Yoshimura

Highlights
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The deletion of NR4a1/2 in T cells enhances anti-tumor immunity
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Loss of NR4a1/2 increases TCF1+ stem-like precursors of exhausted CD8+ T cells
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Lack of NR4a1/2 in T cells promotes glycolysis and oxidative phosphorylation
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NR4a1/2-deficient T cells enhance persistence in the tumor microenvironment