To me, a person that is highly claustrophobic, losing my sight and living in my own little black world (though I know the other senses heighten to overcome the blindness) would be worse than death. Strictly my opinion.
As such, if I knew I was going blind (as do many fungal patients in S America), I would jump on anything and everything that offered any hope of me keeping my sight.
Brilacidin - has been shown to be a possible treatment (a good chance as I read it), and it has no drastically negative history in trials (if given in proper dosages), so I would jump on a treatment with it in a heartbeat. Give me a moderate dosage and if that doesn't work slowly increase until either it does start working or negative effects come about that would be life threatening (and even then I would take it for another test or two).
I may not be the norm, but I am sure there are many thousands of the million people a year that lose their sight due to fungal infection that would also be willing to try such a drug. At the very least, give 100 to 500 people a test with a hearty dose as determined to be the level to cause a positive reaction. If it proves deadly to all, sorry but thank you greatly for providing data to lower the dosage. Once you get it down to a level that works and is safe (say only 100 people per follow up trial at lower dosage) ;you may have lost less than 1000 people and yet you have saved sight for millions.
To me that is a very fair loss as they were all volunteers and I would be the first to sign up for the initial trial. Hope the powers to be in S. America feel the same way. Don't inch up on the problem as is done in America, go in big to a small test group and then scale back immediately should issues arise. That way you don't take years (as FDA did w/ Kevetrin to find it was safe until effectiveness couldn't go any higher) but maybe only six months or so.
About time medicine started changing ways (as in AI saying if dose should be deadly or not) from the old tried and true methods (unless those on the old system were making too much money under the table to keep trials slow, cumbersome, and IMO totally bullshit in many cases).
