Rezolute Inc. (RZLT)

[Whalatane]

Well congrats if you are in EYPT . There are some differences between DME and wAMD ...from ChatGPT

Wet AMD is characterized by the growth of abnormal blood vessels, also known as choroidal neovascularization (CNV), which leak fluid and blood into the macula, leading to rapid vision loss if left untreated.
Treatments for wet AMD often involve anti-vascular endothelial growth factor (anti-VEGF) injections or other therapies aimed at stopping the growth of abnormal blood vessels.
DME (Diabetic Macular Edema):
DME is a complication of diabetic retinopathy, which is a condition caused by damage to the blood vessels in the retina due to diabetes.
In DME, the blood vessels in the retina become leaky, leading to fluid accumulation (edema) in the macula.
This accumulation of fluid causes the macula to swell, leading to blurry or distorted vision, and if left untreated, it can cause vision loss.
Treatments for DME often involve anti-VEGF injections, corticosteroid injections, or laser therapy aimed at reducing the leakage of fluid and improving vision.

In summary, while both wet AMD and DME involve fluid accumulation in the macula leading to vision problems, wet AMD is primarily related to abnormal blood vessel growth due to aging, while DME is a complication of diabetic retinopathy resulting from diabetes-related damage to retinal blood vessels.

So the disease process is different ...DME specific to diabetics with the MOA ( method of action ) of RZ402 primarily being anti inflammatory / anti leakage .....not slowing / preventing abnormal growth of blood vessels ( wAMD )

Just my layman's take on this ...Thx for your question as its lead me to more research in the area.

They are hoping RZ402 can be used as an easy treatment for the early stages of DME.

Kiwi