Jaguar Health Inc (JAGX)

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Our B2i Digital featured company, Jaguar Health (NASDAQ: JAGX), provided an update that a preclinical study initiated in Brazil by their mental health-focused joint venture, Magdalena Biosciences, shows psychoactive activity in a lead botanical drug candidate.

According to the announcement, mice experiments with this plant extract demonstrated increased brain metabolism, indicating potential benefits for conditions like ADHD, anxiety, and depression. Full press release: https://lnkd.in/eMPnaM_d

Jaguar’s EVP of Corporate and Business Development and the Acting CEO of Magdalena, Dr. Karen J. Brunke, commented, “We are very excited with the result of this study and are especially encouraged that the analysis shows changes in neuronal connectivity with important implications for disease treatment which will be further studied in a clinical study. Magdalena’s goal is to identify effective, plant-based, next-generation psychoactive drugs that are safe, can be taken at home, and can be used on a long-term basis. We aim to enter the clinic in 2024 with at least one botanical drug candidate after an IND (Investigational New Drug) application to the U.S. Food and Drug Administration (FDA) under FDA Botanical Guidance. Following activation of this IND by the FDA, Magdalena may be able to go directly into a Phase II clinical trial for the extract, with no need for a Phase I trial.”

Steven King, Ph.D., Jaguar’s Chief Sustainable Supply and Ethnobotanical Research Officer, and an Advisor to Magdalena, also noted in the release, “Like Jaguar, Magdalena was formed to harness the power of ethnobotany and indigenous knowledge to identify and evaluate traditional medicines that have been utilized for hundreds or thousands of years to look for medications that are likely to be safe and effective - with a goal of bringing these novel therapies to a wider market as approved, sustainably derived prescription pharmaceuticals. Earth’s rainforests are often described as nature’s largest medicine cabinets - and for good reason, as many of the world’s important pharmaceutical medicines were discovered by studying the traditional medicine of indigenous peoples.”

Jaguar is collaborating with Filament Health on Magdalena to advance plant-based psychedelic medicines.

B2i Digital sends our continued good wishes to CEO Lisa Conte, Chief Scientific Officer Pravin Chaturvedi, Peter C. H. and the entire Jaguar team, who are on the front lines of scientists discovering new treatments against catastrophic medical situations.

Learn more about Jaguar Health and Magdalena Biosciences and stay current on the company and its latest news. Featured Company profile: https://lnkd.in/exkQ2dbF

#biotech #pharma #raredisease #clinicaltrials #healthtech #B2iDigital #JaguarHealth #Depression #Ethnobotany #RainforestPlants #animalhealth #plantbased