Idenix Pharmaceuticals (IDIX)

[gofishmarko]

Re : SGP + WYE/VPHM?

'Last call' is approaching and the couples ( and triples ) are hooking up. Here's a new abstract on the same topic :

http://jvi.asm.org/cgi/content/abstract/81/6/3005?etoc

Journal of Virology, March 2007, p. 3005-3008, Vol. 81, No. 6

Copyright © 2007, American Society for Microbiology.

Synergy of Small Molecular Inhibitors of Hepatitis C Virus Replication Directed at Multiple Viral Targets

David L. Wyles,1* Kelly A. Kaihara,1 Florin Vaida,2 and Robert T. Schooley1
Department of Medicine, Division of Infectious Diseases,1 Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, California2

Received 22 September 2006/ Accepted 10 December 2006

Chronic hepatitis C virus (HCV) infection is a significant worldwide health problem with limited therapeutic options. A number of novel, small molecular inhibitors of HCV replication are now entering early clinical trials in humans. Resistance to small molecular inhibitors is likely to be a significant hurdle to their use in patients. A systematic assessment of combinations of interferon and/or novel anti-hepatitis C virus agents from several different mechanistic classes was performed in vitro. Combinations of inhibitors with different mechanisms of action consistently demonstrated more synergy than did compounds with similar mechanisms of action. These results suggest that combinations of inhibitors with different mechanisms of action should be prioritized for assessment in clinical trials for chronic hepatitis C virus infection.



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* Corresponding author. Mailing address: 9500 Gilman Drive, MC 0711, La Jolla, CA 92093. Phone: [phone]. Fax: [phone]. E-mail: [e-mail].

Published ahead of print on 20 December 2006.