Sunday, January 14, 2024 8:46:01 AM
4. Medicines for lung function
The vital task of the lungs is to ensure the exchange of gases between the air we breathe and the blood. Seriously ill corona patients are in danger of losing their lives if this no longer works sufficiently. What is then essential for recovery is that the lungs can regenerate with functional tissue and not just scar tissue.
One of the drugs being tested for maintaining lung function contains the active ingredient Aviptadil, a synthetic version of the naturally occurring molecule VIP in humans. The Swiss company Relief Therapeutics has approval in the EU for the treatment of acute respiratory distress syndrome (ARDS) and sarcoidosis, but has not yet brought it onto the market in Germany. The active ingredient works, among other things: anti-inflammatory and protects certain lung cells (alveolar type 2 cells) from viral attack. They are a preferred target of SARS-CoV-2 and are particularly important for maintaining lung function. Following positive laboratory data, the company NeuroRx conducted a phase II/III study with seriously ill Covid-19 patients (symptoms of severe lung failure; ventilated) in the USA with the support of Relief Therapeutics. With intravenous therapy, patients recovered more quickly from respiratory symptoms. NeuRx then applied for an Emergency Use Authorization from the FDA. A long-term study (1 year follow-up) with patients with serious previous illnesses suggested that VIP improved their survival by 60%. However, in another study with seriously ill Covid-19 patients, Aviptadil did not show any effectiveness. Relief Therapeutics has also started a phase II study with an inhalable formulation of the active ingredient together with the company AdVita Lifescience in Saarbrücken. The aim here is also to avoid acute respiratory distress syndrome in Covid-19 patients.
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