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Re: RVNCfan post# 249454

Friday, 10/20/2023 7:11:22 PM

Friday, October 20, 2023 7:11:22 PM

Post# of 252233

[AEON/RVNC]—Abbvie…started Phase-3 trial in Episodic Migraine so I thought it would be easy to meet the endpoint.

Clinical trials where the efficacy endpoint is subjective (i.e. how the patient feels rather than an empirical measurement) tend to have high failure rates even if the drug being tested has bona fide activity.

As a RVNC shareholder, I won’t object if RVNC opts to forgo Daxxify trials in such indications as migraine and depression.

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