Omega Therapeutics Inc (OMGA)

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Omega Therapeutics Announces Two Poster Presentations on Liver Inflammation and Fibrosis at AASLD’s The Liver Meeting® 2023
October 11 2023 - 04:00PM
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Omega Therapeutics, Inc. (Nasdaq: OMGA) (“Omega”), a clinical-stage biotechnology company pioneering the development of a new class of programmable epigenomic mRNA medicines, today announced that it will present new preclinical data demonstrating the potential of epigenomic controllers for the treatment of inflammatory and fibrotic liver diseases at the American Association for the Study of Liver Diseases’ (AASLD) The Liver Meeting® 2023, taking place in Boston, Massachusetts, November 10 – 14.
“Our OMEGA platform enables us to rationally and rapidly design epigenomic controllers to bidirectionally tune the expression of one or multiple genes pre-transcriptionally,” said Mahesh Karande, President and Chief Executive Officer of Omega Therapeutics. “These preclinical data demonstrate the potential of programmable mRNA development candidates to controllably upregulate the expression of a single gene to drive liver regeneration in models of fibrosis, as well as the ability to simultaneously downregulate the expression of multiple genes linked to inflammatory liver diseases with a single epigenomic controller. Together, these findings underscore the versatile capabilities of our OMEGA platform and the potential of precision epigenomic control to address a broad range of diseases.”

Details for the poster presentations are as follows:

Title: Targeting CXCL9/CXCL10/CXCL11 using novel epigenomic controllers for the treatment of inflammatory liver disease
Poster number: 2621-A
Date and Time: November 11, 2023, from 1:00 p.m. to 2:00 p.m. ET
This poster has been selected by AASLD as a “Poster of Distinction”, having been classified as being in the top 5% of scored poster abstracts and will receive special recognition in the Poster Hall.

Title: Induction of Hepatocyte Nuclear Factor 4 alpha (HNF4a) using novel epigenomic controllers
Poster number: 3444-A
Date and Time: November 12, 2023, from 1:00 p.m. to 2:00 p.m. ET

The posters will be made available on the Omega website at https://omegatherapeutics.com/our-science/#publications-research at the same time as the presentations.

About the OMEGA Platform

The OMEGA platform leverages the Company’s deep understanding of gene regulation, genomic architecture and epigenetic mechanisms to design programmable epigenomic mRNA medicines that precisely target and modulate gene expression at the pre-transcriptional level. Combining a biology-first approach and world-class data science capabilities with rational drug design and customized delivery, the OMEGA platform enables control of fundamental epigenetic processes to correct the root cause of disease by returning aberrant gene expression to a normal range. Omega’s investigational programmable mRNA medicines, Epigenomic Controllers, target specific genomic loci within insulated genomic domains with high specificity to durably tune single or multiple genes to treat and cure diseases through unprecedented precision epigenomic control.

About Omega Therapeutics

Omega Therapeutics is a clinical-stage biotechnology company pioneering the development of a new class of programmable epigenomic mRNA medicines to treat or cure a broad range of diseases. By pre-transcriptionally modulating gene expression, Omega’s approach enables controlled epigenomic modulation of nearly all human genes, including historically undruggable and difficult-to-treat targets, without altering native nucleic acid sequences. Founded in 2017 by Flagship Pioneering following breakthrough research by world-renowned experts in the field of epigenetics, Omega is led by a seasoned and accomplished leadership team with a track record of innovation and operational excellence. The Company is committed to revolutionizing genomic medicine and has a diverse pipeline of therapeutic candidates derived from its OMEGA platform spanning oncology, regenerative medicine, multigenic diseases including immunology, and select monogenic diseases.

For more information, visit omegatherapeutics.com, or follow us on X (formerly Twitter) and LinkedIn.