Ventyx Biosciences Inc (VTYX)

[DewDiligence]

VTYX—(-20%/AH)—reports purportedly-positive phase-2 data_in UC:

https://www.globenewswire.com/news-release/2023/10/09/2757021/0/en/Ventyx-Biosciences-Announces-Positive-Results-from-the-Phase-2-Trial-of-VTX002-in-Patients-with-Moderate-to-Severely-Active-Ulcerative-Colitis.html

The Phase 2 trial of VTX002 was a 13-week, randomized, double-blind, placebo-controlled, dose-ranging trial evaluating the efficacy and safety of two oral doses of VTX002 (30 mg and 60 mg once daily) in patients with moderate-to-severely active UC. The primary endpoint was the proportion of patients achieving clinical remission at Week 13 as defined by the modified Mayo Clinic Score.

…28% of patients on the 60 mg dose and 24% of patients on the 30 mg dose achieved the primary endpoint of clinical remission at Week 13 compared to 11% of patients on placebo (p=0.018 for 60 mg; p=0.041 for 30 mg).

I.e., the absolute effect size was less than some investors apparently expected.

Note: VTX202, an S1P1 modulator, should not be confused with VTX958, a TYK2 inhibitor.