Innovation Pharmaceuticals Inc (IPIX)

[farrell90]

Brilacidin was studied as an eye drop for bacterial keratitis and was shown to be equivalent to Vancomycin against multiple resistant staph aureus

"Conclusions: BRI has Gram-positive in vitro activity; topical BRI 0.5% was minimally irritating; and BRI 0.5% was equally efficacious as VAN in a MRSA keratitis model when the corneal epithelium was removed. "

https://pubmed.ncbi.nlm.nih.gov/26501484/

Adenoviral keratoconjunctivitis is often referred to as epidemic keratoconjunctivits and out breaks are common world wide. While it can produce severe symptoms it usually resolves in a few weeks and unlike bacterial and fungal keratitis it is not a cause of permanent eye damage or visual loss. Infrequently the symptoms can last for a few months.

To the best of my knowledge Brilacidin has not been tested against Adenoviruses.

Your comment regarding the Brilacidin eye drop has validity. Fungal keratitis is becoming more common in the Northern hemisphere as the world wide temperature has increased. Fungal keratitis is much more common in tropical countries and the southern US, especially Florida.

At times fungal keratitis responds poorly to topical anti-fungal medications and has a higher rate of permanent corneal scarring, permanent visual loss and even loss of the eye. Corneal scarring at times requires corneal transplantation to improve vision.

IMO Brilacidin has a high probability of being approved for fungal diseases and fungal keratitis. The topical eye drop could be the first Brilacidin approved treatment in humans.

Antibiotic, antiviral and antifungal eye drops are all prescription and will require full testing. There is no reason to believe Brilacidin as a topical eye drop will ever be released over the counter in the United States.

Many other countries do allow antibiotics and topical antibiotic eye drops to be dispensed without a prescription. I have been told one can go to Tijuana, Mexico and buy antibiotics without prescriptions.

Good luck,Farrell