Novocure Ltd (NVCR)

[dstock07734]

Read the story about Owain who had 50% of GBM tumor removed and who tumor tissue was only enough to make three doses of the DCVax-L vaccine. But as his doctor, the world renowned neurosurgeon, said, three doses are enough to reprogram the whole immune system. Owain scanned results showed that the rest of 50% of the tumor shrunk into a small cyst and it keeps shrinking four months after the last shot.

https://www.justgiving.com/crowdfunding/owainjames

You want to know why? The reason is that DCVax-L can activate CD4 t cells which play a critical role in the formation and maintenance of immune memory. The MHC Class 2 molecules can only be found in antigen presenting cells which are only few types in human, such as dendritic cells, B-cells, macrophages. Only these molecules can activate CD4 t cells. Read what Dr. Bosch said in the present in June.

It presents peptides from both known GBM-associated tumor antigens, and tumor antigens which have not been reported in GBM before. And the presentation of these peptides, not only through class 1, remember important for cytotoxic T cells, but also through Class 2, to CD4 T cells, suggests that we also get T-cell memory responses in vivo. Something of course, that we believe is incredibly important in a chronic disease like GBM, where you can't just eradicate it at once. You needed ongoing response that continues to hammer away at the tumor. You need to set up that battle in the brain, where the immune system can continue to eradicate tumor cells, because they will continue to replicate otherwise. So this immune memory is actually critical for the, for the potential success.

Take a look how many t-cells in those patients 4 and 8 months after the last shot of the vaccine. Pay specific attention to see how many t-cells normal person has.

The writing on the wall is clear. What are you waiting for?