Biotech Values

[vinmantoo]

Going to be hard to treats pts with a direct acting antiviral if there is no more virus there.

Pretty amazing how someone without any knowledge on the topic can summarily dismiss the possibility that at least a sub-set of long Covid patients are suffering from viral persistence arising from hidden viral reservoirs.

Below is a quote from a recent article published in Nature on the topic of long Covid.

Several reports have pointed towards possible viral persistence as a driver of long COVID symptoms; viral proteins and/or RNA has been found in the reproductive system, cardiovascular system, brain, muscles, eyes, lymph nodes, appendix, breast tissue, hepatic tissue, lung tissue, plasma, stool and urine55,56,57,58,59,60. In one study, circulating SARS-CoV-2 spike antigen was found in 60% of a cohort of 37 patients with long COVID up to 12 months after diagnosis compared with 0% of 26 SARS-CoV-2-infected individuals, likely implying a reservoir of active virus or components of the virus16. Indeed, multiple reports following gastrointestinal biopsies have indicated the presence of virus, suggestive of a persistent reservoir in some patients58,61.

A recent report from NPR on the topic of long Covid and the evidence for a role of viral reservoirs.

https://www.npr.org/sections/health-shots/2023/05/02/1172806898/why-viral-reservoirs-are-a-prime-suspect-for-long-covid-sleuths

How about a recent publication in eLife?

https://elifesciences.org/articles/86015