Fate Therapeutics Inc (FATE)

[jondoeuk]

From another group https://www.cell.com/iscience/fulltext/S2589-0042(23)01155-0

I know the founder of ONK Therapeutic has talked about (low-dose) bortezomib, which upregulates expression of DR5 sensitising cancer cells to TRAIL-mediated apoptosis https://aacrjournals.org/cancerres/article/66/14/7317/525881/Bortezomib-and-Depsipeptide-Sensitize-Tumors-to

It also upregulates Fas https://journals.aai.org/jimmunol/article/180/1/163/78395/Sensitization-of-Tumor-Cells-to-NK-Cell-Mediated

In addition, Treg depletion is another way that could increase efficacy https://ashpublications.org/blood/article/113/24/6120/25786/Bortezomib-treatment-and-regulatory-T-cell