The main point here is that ADCs are easy (relatively) so there are hundreds of them in pipelines for many different indications.
Again I make no argument about clinical value, particularly relative to conventional chemotherapy, just that dozens of companies and multiple molecules per target make this a poor space from an investment standpoint.
And setting aside first-gen agents with unstable linkers, I really don't think different linker technologies are going to make a meaningful difference in efficacy. I don't know how you can say they "make a big difference in safety" without a true head-to-head.
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