In AML that would be patients at a high risk of relapse, as defined by CR following induction, but are MRD+, and/or with incomplete recovery of neutrophil (CRi) or platelet counts (CRp). In that group more than 80% will relapse within the first year no matter what is (currently) done after induction therapy https://ascopubs.org/doi/full/10.1200/JCO.2014.58.3518
I also know of a PhI/II trial testing auto CD8+ (central memory vs. naïve phenotype) T-cells transduced using a viral vector to target WT1. Of seven treated, four are NED, with the other three relapsing. There are data from two (the third declined additional treatment before passing away) showing one was due to WT1 negative disease and the other was due to failure of T-cells.
WT1 is an oncogene and also expressed on leukemic stem cells https://www.nature.com/articles/nature22993
Looking at the patient who was WT1 negative, their disease was found to express CCNA1, so could be targeted with a different TCR https://ashpublications.org/bloodadvances/article/4/2/387/440610/Evaluation-of-cyclin-A1-specific-T-cells-as-a
As for the second, immunosuppressive and rapid proliferation of the disease were likely the reason, so other modifications to T-cells will be needed to address both, such as this https://ashpublications.org/blood/article/130/22/2410/36564/A-CD200R-CD28-fusion-protein-appropriates-an
Recent TCRX News
- TScan Therapeutics Announces First Patient Dosed in Phase 1 Clinical Trial Evaluating TCR-T Therapy for the Treatment of Solid Tumors • GlobeNewswire Inc. • 05/09/2024 11:00:00 AM
- TScan Therapeutics Announces Upcoming Presentations at the 2024 American Society of Clinical Oncology Annual Meeting • GlobeNewswire Inc. • 04/24/2024 08:05:34 PM
- TScan Therapeutics Announces Exercise of Underwriters' Option to Purchase Additional Shares • GlobeNewswire Inc. • 04/24/2024 03:03:30 PM
- TScan Therapeutics Announces Upcoming Presentations at the American Society of Gene and Cell Therapy 27th Annual Meeting • GlobeNewswire Inc. • 04/22/2024 09:01:23 PM
- TScan Therapeutics Announces Closing of Upsized Public Offering • GlobeNewswire Inc. • 04/19/2024 02:05:23 PM
- TScan Therapeutics Announces Pricing of Upsized $150 Million Public Offering • GlobeNewswire Inc. • 04/17/2024 04:30:57 AM
- TScan Therapeutics Announces Launch of $125 Million Proposed Public Offering • GlobeNewswire Inc. • 04/16/2024 08:25:22 PM
- TScan Therapeutics Provides Clinical Pipeline Update and Highlights Near-Term Priorities • GlobeNewswire Inc. • 04/16/2024 08:01:00 PM
- TScan Therapeutics Appoints Seasoned Hematology and Oncology Expert Chrystal U. Louis, M.D., M.P.H., as Chief Medical Officer • GlobeNewswire Inc. • 04/08/2024 12:00:00 PM
- TScan Therapeutics Announces Upcoming Presentation at the 23rd Annual Needham Virtual Healthcare Conference • GlobeNewswire Inc. • 04/02/2024 11:00:00 AM
- Form S-3 - Registration statement under Securities Act of 1933 • Edgar (US Regulatory) • 03/06/2024 09:11:41 PM
- Form S-8 - Securities to be offered to employees in employee benefit plans • Edgar (US Regulatory) • 03/06/2024 09:05:39 PM
- Form 10-K - Annual report [Section 13 and 15(d), not S-K Item 405] • Edgar (US Regulatory) • 03/06/2024 12:30:34 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 03/06/2024 12:15:10 PM
- Form SC 13G/A - Statement of acquisition of beneficial ownership by individuals: [Amend] • Edgar (US Regulatory) • 02/14/2024 09:45:41 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 01/29/2024 12:15:03 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 12/11/2023 01:00:03 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 12/07/2023 12:15:01 PM
- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 11/09/2023 12:30:23 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 11/09/2023 12:15:08 PM
- TScan Gets FDA Clearance of Investigational New Drug Application for Cancer Treatment • Dow Jones News • 08/29/2023 12:02:00 PM
- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 08/10/2023 11:30:55 AM
- Form 8-K - Current report • Edgar (US Regulatory) • 08/10/2023 11:15:53 AM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 07/24/2023 11:39:09 PM
- Form 3 - Initial statement of beneficial ownership of securities • Edgar (US Regulatory) • 07/24/2023 11:31:00 PM
Avant Technologies Equipping AI-Managed Data Center with High Performance Computing Systems • AVAI • May 10, 2024 8:00 AM
VAYK Discloses Strategic Conversation on Potential Acquisition of $4 Million Home Service Business • VAYK • May 9, 2024 9:00 AM
Bantec's Howco Awarded $4.19 Million Dollar U.S. Department of Defense Contract • BANT • May 8, 2024 10:00 AM
Element79 Gold Corp Successfully Closes Maverick Springs Option Agreement • ELEM • May 8, 2024 9:05 AM
Kona Gold Beverages, Inc. Achieves April Revenues Exceeding $586,000 • KGKG • May 8, 2024 8:30 AM
Epazz plans to spin off Galaxy Batteries Inc. • EPAZ • May 8, 2024 7:05 AM