Fate Therapeutics Inc (FATE)

[jondoeuk]

It will be interesting to see the design of the CAR-Macs. In this, they designed ways to enhance phagocytosis https://elifesciences.org/articles/36688

In another, the group added CD147 as a transmembrane and intracellular signaling domain to activate the expression of matrix metalloproteinases, which are stimulated by CD147 and can degrade the tumour extracellular matrix to overcome physical barriers https://www.nature.com/articles/s41416-019-0578-3

So, hopefully will look at both. Shoreline also talk about adding an anti-CD47 mAb, but I hope they drop that and look at gene editing https://jitc.bmj.com/content/jitc/9/Suppl_2/A152.full

Building on that would be the local secretion of different molecules https://jitc.bmj.com/content/10/Suppl_2/A396