ANI Pharmaceuticals (ANIP)

[Just the facts maam]

Silvr, we know that Novitium had three 505(b)(2) drugs for hypertension and oncology in the works when acquired. It looks like oral suspension Hhydrochlorothiazide was one, another being Terazosin Oral liquid which probably won't be as lucrative.

In 2020, 2,285,079 prescriptions of Terazosin were issued at average of 15.53 (generic drug). I figure it will likely generate peak sales of $60 million, unless the oral solution brings back patients who used nearly 6 million prescriptions in 2013. If so, you could be looking at $120 million a year in peak sales.

Not sure what the third drug will be unless it is Carglumic Acid which they have a patent for an easier to store version of Carbaglu.

Interestingly a study found that carglumic acid induced apoptosis in various cancer cells in vitro.

Drug repurposing offers the advantages of time and cost savings stemming from the fact that the drug being repurposed has already passed toxicity and safety testing and therefore has a reduced chance of failur]. In this study, we found that carglumic acid, which is conventionally used to treat hyperammonemia, has anticancer activity. We found that carglumic acid induced apoptosis in various cancer cells in vitro. Our results indicated that carglumic acid inhibits proliferation of human pancreatic cancer, triple-negative breast cancer, hepatoma, and lung cancer cells by inducing apoptosis. Importantly, carglumic acid is a relatively safer anti-cancer agent than gemcitabine or paclitaxel, which is in agreement with the fact that no serious safety issue has been identified for the use of carglumic acid in treatment of hyperammonemia. Carglumic acid also demonstrated potent antitumor activity in vivo in orthotopic mouse models of human pancreatic and breast cancer. Together, these findings demonstrate a novel anticancer function of carglumic acid, with less toxicity than that of chemotherapeutic agents. Carglumic acid therefore represents an effective alternative for cancer treatment.

Study

Good luck to everyone tomorrow.