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Wednesday, May 03, 2023 2:34:45 PM
"Additionally, the Company and University of São Paulo (USP), Brazil, have entered into a collaborative research agreement to investigate the broad-spectrum activity and treatment potential of Brilacidin in fungal diseases. Under terms of the agreement, USP researchers are to conduct pre-clinical efficacy, mechanism, resistance and immunological studies of Brilacidin against Aspergillosis, Cryptococcus and Candida. Separate in vitro testing of Brilacidin’s antifungal properties is underway by NIH/NIAID-affiliated researchers, with potential to bridge into in vivo models, formulation development support and clinical testing."
https://www.ipharminc.com/press-release/2023/2/23/innovation-pharmaceuticals-visits-beamed-new-stingray-laser-system-for-epilepsy-and-brain-tumors-moving-toward-fda-submission
"“There is a critical need for new antifungal agents,” commented Gustavo H. Goldman, Professor of Molecular Biology, at the University of São Paulo (USP), Brazil, and a Chief Editor for Frontiers in Fungal Biology. “The clinical utility of currently available antifungal treatments is limited due to emerging drug resistance, toxicity, fungistatic and not fungicidal properties, as well as drug interaction concerns. Brilacidin’s ability to potentiate marketed antifungals, such as caspofungin, in multiple human pathogenic fungi, while showing strong stand-alone potency against the hard-to-treat fungal pathogen, C. neoformans, clearly supports Brilacidin’s potential to be developed as a novel antifungal. Myself, along with team members, are looking forward to exploring Brilacidin’s direct antifungal activity and possible favorable modulation of the host response following infection.”
Dr. Goldman, a co-author of the Nature Communications paper, has now agreed to join the Company as a Scientific Advisor, helping guide the study of Brilacidin in the area of mycology and fungal diseases. He is an expert in fungal genetics and antifungal resistance and his laboratory at USP focuses on the molecular biology of human fungal pathogens. Among his scientific achievements, Dr. Goldman has authored over 300 publications, is a member of the Brazilian Academy of Sciences, and a fellow of the American Academy of Microbiology and European Confederation of Medical Mycology."
https://www.ipharminc.com/press-release/2023/4/17/innovation-pharmaceuticals-brilacidin-antifungal-research-published-in-nature-communications
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