I'm surprised at how many patients here had surface Ag <100, 5/18 in the two groups highlighted. I would imagine that in the real world only 5% or so of patients w chronic hep B have that low of a level. In the Bepirovirsen 2b study 7 out of 138 patients on the high dose/duration arm had HBSAg levels <200 (all had undetectable levels at EOT, and 6/7 maintained this to 6 months post tx). (Figure S9 https://www.nejm.org/doi/full/10.1056/NEJMoa2210027). GSK's phase 3 is enrolling patients with surface Ag <3000, and has a predefined look at efficacy in those <1000. I know several companies have therapeutic vaccines in the pipeline and this could be a component of combination therapy at some point but clearly too weak as a monotherapy to amount to anything
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