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Post# of 252302
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Alias Born 10/05/2005

Re: None

Tuesday, 03/28/2023 7:08:45 AM

Tuesday, March 28, 2023 7:08:45 AM

Post# of 252302
VKTX

Well I haven't looked at the data in detail yet but it appears that VKTX's VK2735 blew away other agents in the class

In the 28-day MAD portion of the study, VK2735 demonstrated encouraging tolerability and positive signs of clinical activity. All cohorts receiving VK2735 demonstrated reductions in mean body weight from baseline, ranging up to 7.8%. Cohorts receiving VK2735 also demonstrated reductions in mean body weight relative to placebo, ranging up to 6.0%. Statistically significant differences compared to placebo were maintained or improved at the Day 43 follow-up time point, 21 days after the last dose of VK2735 was administered. The company believes tolerability data from this study indicate that higher doses may be achieved with longer titration windows. Viking plans to evaluate further dose escalation in the upcoming Phase 2 trial.

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