For all new investors I would like to give a background as to why so many long term investors are so irate with the medical community, government, allotment of drug development dollars, etc. It is not just because our investment has tanked, it is because we have had a couple of drugs that look like world class life changing drugs that have been totally ignored even when they have shown GREAT potential in earlier studies.
In this post, I will not say anything about Brilacidin as that is worthy of a separate post that I will most likely get to over the weekend. This post is about the company's cancer drug, Kevetrin, the main reason we old timers got into this investment.
Kevetrin was invented by Dr. Krishna Menon, an Indian doctor that led the development of 2 major cancer drug winners for E I Lilly Pharmaceutical Co. in his role as Group Leader, Cancer Invivo Research and Development. He won major awards for this work so it is not as though he was unknowing as to drug development. While working on a bull in the Caribbean as a veterinary surgeon and as the Chief of Agriculture for the Cayman Islands he had a bull come in for hoof and mouth disease. He found that it also was plastered throughout with tumors. He gave it an accepted animal drug for Hoof and Mouth Disease but the bull died. When he cut open the bull to find what specifically caused the death he found that almost all the tumors were gone. He was quite stunned. He took that animal drug and thru his own lab, KARD Research in Boston, he came to develop Kevetrin.
The BIG, BIG hope for Kevetrin was based on the fact that it was the ONLY drug that could turn on the p53 gene. This gene dealt with the body's natural defense and somehow cancer cells were able to turn it off. Kevetrin turned it back on and along with the p21 gene it was said to be able to induce the body's own natural defenses to be able to kill cancer cells, pretty much ALL cancer cells. It was said at the time that the p53 was the most studied subject in the history of medicine. Think about it, a cancer drug that was NON-TOXIC and worked thru natural body processes. The other phenomenal attribute of the drug was that it was said by Dr. Emil Freirich, the acknowledged father of successful treatment of Child Leukemia cases thru his novel idea of combining various treatments together, that if Kevetrin was a kitchen component it would be like sugar or salt in that it could be combined with everything. Think about that, it could be combined with ALL current toxic cancer drugs (which at the time were said to work like agent orange in the body as they killed ALL cells, not just cancer cells) and it made these toxic drugs much less harmful to the body. The thought by IPIX investors was that BP would flock to Kevetrin to make up a cocktail drug combining their drug with K and thus also greatly prolong the patent rights to their drug in this new form.
Studies indicated it could work on retinoblastoma in children where the cancer starts growing right out of the pupil of the eye. Another study put K with a BP cancer drug and the testing showed a reduction in cervical cancer tumors for the first time ever. Yet another study by the U of Bologna in Italy also found extremely positive testing results in some studies of K. To this day, not one damn advancement in any of these major problem areas by the medical community. Why??? Is the Cancer Foundation lacking for funds?? LOL Or is it against the priorities of the largest cancer research organization to actually CURE cancers, not just treat them for life?? If one looks at the enormous amount of jobs that would be lost if cancer was ever cured, one can see that to a VAST number of people that wouldn't be in their best interests. It would be in the best interests of the patients, but it seems they rank much lower on the priority totem pole. This is all strictly my view of the situation.;
IPIX went to a P1 trial (P1 strictly confirms identifying the safety profile of a drug) and the damn trial took a little over 2 years or so to complete (I am not exactly sure but it was a hell of a long time) at the Boston hospital aligned with Harvard (Sloan-Kettering Hospital). Couldn't do much better as to professional validity. What was shocking was that they started the trial at about 2-5 units (I say units as I am unaware of dosage level) but they went up so slowly that it took forever. Long story short, about 2 years later they had done a test for 600 units and all was well. They went up to 800 units and found the additional dosage did nothing positive though it was still perfectly safe. Thus, they ended the trial as no need to go further and they knew 600 units was the max dosage they needed to give and still get 100% efficiency. Also note that each trial took about 2-3 months. So the questions I asked were as follows: what imbecile started the dosage so low that it was basically saline solution, why did they only go up 5, then 10, then 20, etc instead of going much higher and backtracking if necessary as there were only a very few patients in each trial and ALL were terminal so if a few died they weren't really deprived of any meaningful portion of their life and their sacrifice may have helped save many, many others down the line, once they saw the tremendously safe profile of the drug how come NO other BP investigated its use with their current cancer drug, how come no funds came from any portion of government, medical, or charitable organizations, etc, etc. To me there was a complete burying of the drug as IMO they knew it could radically change the treatment and outcome for some types, possibly many types of cancers.
Dr. Freirich stated that he though Kevetrin could possibly work in 50% or more of ALL cancers, IPIX hired the BEST patent attorney for new drugs to make sure they covered all the bases due to the potential of K, there was another very highly touted medical researcher from I believe Columbia U that was on board that was entranced with K, and yet here we sit about a decade later and Kevetrin has not only NOT advanced at all in any theater of cancer research, IPIX suddenly removed it from their website due to lack of funds for further investigation for the foreseeable future and possibly forever if our financial situation doesn't change.
To put it all in a nutshell, the treatment of Kevetrin by medicine is akin to somebody coming up with a transportation device that utilized hydrogen and thus could be acquired at minimal cost with no damage to the environment and the only byproduct would be H2O, it would get very good mileage, and it would be extremely safe as it could be hooked up to an electric motor. Yet it gets buried - would the general public allow that? Well, that is basically what has happened to Kevetrin.
So am I pissed? More than just a little, I believe people should have been sentenced to death for holding this drug back from the public.
My next post will be about Prurisol and following that it will deal with Brilacidin.
