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Re: PJ007 post# 396497

Wednesday, 02/22/2023 12:02:36 PM

Wednesday, February 22, 2023 12:02:36 PM

Post# of 402724
B-UC is on the shelf, as stated by Leo.

IBD, Ulcerative Colitis (UC) - Brilacidin has also been developed as a treatment in more extensive forms of IBD. Development of a delayed release oral formulation has been in progress, with development work expanding into immediate release formulations due to unexpected findings encountered. Such findings appear due to the inherent physiochemical properties of the compound, and those of polymers used to achieve delayed release. An immediate release, multi-particulate, capsule formulation has been developed, although further work has since been halted due to instability of that formulation being identified. Hence, further advancement in the indication of ulcerative colitis requires conduct of additional formulation development work prior to Phase 1 testing of that oral formulation. Completion of formulation/analytical development work, clinical trial supply manufacturing, and subsequent progression into clinical trials, are pending securing sufficient drug supply and working capital.



https://www.sec.gov/ix?doc=%2FArchives%2Fedgar%2Fdata%2F0001355250%2F000147793223001071%2Fipix_10q.htm

Another failure......lets go Alfasigma.....get it going!!!!




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