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Re: frenchbroad post# 396111

Thursday, 02/02/2023 11:08:05 AM

Thursday, February 02, 2023 11:08:05 AM

Post# of 402726
What is the global impact of tuberculosis?

In 2018, 1.7 billion people were infected by TB bacteria — roughly 23% of the world’s population. TB is the leading infectious disease killer in the world, claiming 1.5 million lives each year.

Of the 10 million individuals who became ill with TB in 2018, approximately three million were “missed” by health systems and do not get the care they need, allowing the disease to continue to be transmitted.


https://www.cdc.gov/globalhealth/newsroom/topics/tb/index.html

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Here is the full research document. I add the underline.
*The CFU by spread plate method showed in DDP combined with p53 promoter (Kevetrin hydrochloride) group decreased significately compared with DDP group (p<0.0001), while the number of colonies in DDP combined with p53 inhibitor (Pifithrin -a hydrobromide) group increased greatly compared with DDP group (p<0.0001) (Fig 4C). Moreover, the bacterial number in cells could also be significantly reduced by using Kevetrin hydrochloride alone, and this effect was positively correlated with the concentration of the p53 promoter (Fig 4D). Compared with RIF, RIF combined with Kevetrin hydrochloride had a stronger effect on the elimination of intracellular mycobacteria (Fig 4E).*

https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=&ved=2ahUKEwj7mJankPX8AhWTSTABHdGlC7oQFnoECCUQAQ&url=https%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%2Fasset%3Fid%3D10.1371%2Fjournal.pone.0281170.PDF&usg=AOvVaw1p4J5vC2wErHmVNA5Labuq
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