Thursday, February 02, 2023 11:08:05 AM
https://www.cdc.gov/globalhealth/newsroom/topics/tb/index.html
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Here is the full research document. I add the underline.
*The CFU by spread plate method showed in DDP combined with p53 promoter (Kevetrin hydrochloride) group decreased significately compared with DDP group (p<0.0001), while the number of colonies in DDP combined with p53 inhibitor (Pifithrin -a hydrobromide) group increased greatly compared with DDP group (p<0.0001) (Fig 4C). Moreover, the bacterial number in cells could also be significantly reduced by using Kevetrin hydrochloride alone, and this effect was positively correlated with the concentration of the p53 promoter (Fig 4D). Compared with RIF, RIF combined with Kevetrin hydrochloride had a stronger effect on the elimination of intracellular mycobacteria (Fig 4E).*
https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=&ved=2ahUKEwj7mJankPX8AhWTSTABHdGlC7oQFnoECCUQAQ&url=https%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%2Fasset%3Fid%3D10.1371%2Fjournal.pone.0281170.PDF&usg=AOvVaw1p4J5vC2wErHmVNA5Labuq
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