Aptose Biosciences Inc (APTO): The IDH1/IDH2 inhibitors are limited. Y...

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Aptose Biosciences Inc (APTO)

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Re: dcaf7 post# 188

Wednesday, 01/25/2023 11:01:44 AM

Wednesday, January 25, 2023 11:01:44 AM

The IDH1/IDH2 inhibitors are limited. Yes they generate CRs, but most AML patients have multiple mutations, not just IDH1 or IDH2. They are very susceptible to relapse. I believe that TUSP will be much more effective in first line AML if it proves to be safe with HMA + Ven (which I expect). I expect the range of AML patients that will respond to the triplet to include the IDH2 and possible the IDH1mut patients.

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