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Re: Zeppo post# 177

Monday, 01/23/2023 12:04:22 PM

Monday, January 23, 2023 12:04:22 PM

Post# of 575
Yes dosage is pretty well established. They have a wide therapeutic window with TUSP-40mg up to 160mg. They will initiate patients on monotherapy expansion at 120mg and adjust up or down if warranted. They will use the results of the expansion phase to decide what to propose to the FDA for any AA trial. They will initiate the combination trial dose exploration at 80mg.
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