Innovation Pharmaceuticals Inc (IPIX)

[farrell90]

Not so strange articles regarding the Kevetrin's P53 modulating properties against malignancies:

https://pubmed.ncbi.nlm.nih.gov/32945487/

Kumar A, Hiran T, Holden SA, Chafai-Fadela K, Rogers S, Ram S, Menon K. Kevetrin™, a novel small molecule, activates p53, enhances expression of p21, induces cell cycle arrest and apoptosis in a human cancer cell line. Cancer Res. 2011;71:4470.

Kumar A, Holden SA, Chafai-Fadela K, Ram S, Menon KE. Kevetrin targets both MDM2-p53 and Rb-E2F pathways in tumor suppression. Cancer Res. 2012;72:2874

Kumar A, Brennan DP, Chafai-Fadela K, Holden SA, Ram S, Shapiro GI, Menon GI. Kevetrin induces p53-dependent and independent cell cycle arrest and apoptosis in ovarian cancer cell lines representing heterogeneous histologies. Cancer Res. 2017;77:322.

Shapiro G, Supko JG, Cho DC, Hilton JF, Hadfield M, Pruitt-Thompson S, Bordoli-Trachsela E, Zvereva N, Wolanski A, Sato-DiLorenzo A, et al. A phase I, dose-escalation, safety, pharmacokinetic, pharmacodynamic study of thioureidobutyronitrile, a novel p53 targeted therapy, in patients with advanced solid tumors. J Clin Oncol. 2013;31(Suppl 15):TPS2627. doi: 10.1200/jco.2013.31.15_suppl.tps2627. - DOI

https://www.annalsofoncology.org/article/S0923-7534(19)34531-4/fulltext#back-bb0215

GLTA, Farrell