Aptose Biosciences Inc (APTO): Mutations that have yielded a CR with TU...

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Aptose Biosciences Inc (APTO)

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Sunday, 01/22/2023 1:58:36 PM

Sunday, January 22, 2023 1:58:36 PM

Mutations that have yielded a CR with TUSP: FLT3; IDH2; SRSF2; TP53; NPM1; DNMT3a; RUNX1; NRAS; SF3B1; RB1; MLL-PTD; BCOR; U2AF1; SETBP1
Mutations that have yielded a PR with TUSP: KRAS; IDH1; PTPN11; ASXL1; CBL
Preclinical Cell line data suggests the LUX is effective against mutant NRAS; IDH1; SRF2 and ASXL1.
Preclinical Cell line data suggests the LUX is effective against several mutants that are also hit by TUSP leading to potential additive or synergistic effects.
Both TUSP and LUX have very favorable safety profiles and both are synergistically enhanced by venetoclax. They have been combined in vitro (data not shown-yet).
Primary emergent resistance mutants to Gilteritinib are NRAS; KRAS; TP53.

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Recent APTO News

Form 8-K - Current report • Edgar (US Regulatory) • 08/15/2024 08:35:12 PM
Aptose Announces Adjournment of its Special Meeting of Shareholders • GlobeNewswire Inc. • 08/15/2024 08:30:00 PM
Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 08/08/2024 09:22:28 PM
Form 8-K - Current report • Edgar (US Regulatory) • 08/08/2024 09:15:13 PM
Aptose Reports Results for the Second Quarter 2024 • GlobeNewswire Inc. • 08/08/2024 09:06:51 PM
Form 8-K - Current report • Edgar (US Regulatory) • 07/26/2024 08:30:11 PM
Form 8-K - Current report • Edgar (US Regulatory) • 07/19/2024 09:00:14 PM
Aptose Announces Receipt of Deficiency Notice from Nasdaq • GlobeNewswire Inc. • 07/19/2024 09:00:00 PM
Form DEF 14A - Other definitive proxy statements • Edgar (US Regulatory) • 07/17/2024 03:43:45 PM
Form 8-K - Current report • Edgar (US Regulatory) • 06/14/2024 11:40:15 AM
Form 8-K - Current report • Edgar (US Regulatory) • 06/03/2024 08:35:17 PM
Form 8-K - Current report • Edgar (US Regulatory) • 06/03/2024 02:32:05 PM
Form 424B5 - Prospectus [Rule 424(b)(5)] • Edgar (US Regulatory) • 06/03/2024 10:05:42 AM
Form 8-K - Current report • Edgar (US Regulatory) • 05/31/2024 12:05:15 PM
Form DEF 14A - Other definitive proxy statements • Edgar (US Regulatory) • 05/15/2024 03:47:00 PM
Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 05/14/2024 09:06:23 PM
Form 8-K - Current report • Edgar (US Regulatory) • 05/14/2024 08:15:19 PM
Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 05/10/2024 03:35:32 PM
Form 8-K - Current report • Edgar (US Regulatory) • 05/06/2024 08:45:13 PM
Form 8-K - Current report • Edgar (US Regulatory) • 03/01/2024 10:00:16 PM
Form SC 13G/A - Statement of acquisition of beneficial ownership by individuals: [Amend] • Edgar (US Regulatory) • 02/14/2024 09:51:40 PM
Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 02/07/2024 11:06:38 PM
Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 02/07/2024 10:45:35 PM
Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 02/07/2024 10:26:13 PM
Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 02/07/2024 10:15:04 PM

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