Sonnet BioTherapeutics Inc (SONN): Excerpt : "We have evaluated the drug le...

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Friday, 01/20/2023 6:23:52 AM

Friday, January 20, 2023 6:23:52 AM

Excerpt : "We have evaluated the drug levels and cytokine responses in the SB102 study," said Richard Kenney, M.D., Sonnet's Chief Medical Officer. "The PK and PD from 3 cohorts have been formally simulated to predict the levels of the most responsive cytokines. Interferon gamma (IFNg) levels rose after SON-1010 dosing as expected, but with lower peak elevations and much longer decay than those observed historically for rhIL-12, which correlates with better tumor control in preclinical models. Linking IL-12 to the FHAB is designed to permit use of higher doses of this cytokine without triggering unacceptable toxicity, allowing us to safely induce a successful local immune response to IL-12 in the TME."

https://finance.yahoo.com/news/sonnet-biotherapeutics-announces-pharmacokinetic-pharmacodynamic-130000814.html

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