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jondoeuk

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jondoeuk

Re: NY1972 post# 211

Thursday, 01/19/2023 7:48:41 PM

Thursday, January 19, 2023 7:48:41 PM

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Any info on it?

As for CAR-T, I know an anti-mesothelin as shown some activity (SD) in patients with metastatic pancreatic, but Dr. June, has said the CARs rapidly exhaust within a few weeks. He and other groups are trying to overcome that and other barriers https://insight.jci.org/articles/view/99573 https://insight.jci.org/articles/view/96976 https://aacrjournals.org/cancerres/article/82/12_Supplement/569/701712

In addition, a trial testing an anti-mesothelin TCR-T therapy is ongoing (NCT04809766) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724422/
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