At the same time, resistance to Paxlovid is claimed to be developing. https://www.sciencedirect.com/science/article/pii/S0924857922002400 Discussion starts: “2.5. Resistance As with any other antiviral, resistance can be either basal or treatment-emergent. Mutations in Mpro causing resistance to nirmatrelvir are already found in circulating SARS-CoV-2 viruses (Table 1 and Figure 1)…”