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Re: loanranger post# 395295

Monday, 12/12/2022 10:26:10 AM

Monday, December 12, 2022 10:26:10 AM

Post# of 403046
Funny how remdesiver fails it's first clinical trial and is then poo poo'd by the WHO and later becomes a covid-19 darling. Yes B showed strong anti-viral properties in pre-clinical studies also in the small subgroup sample those treated with B early from onset achieved sustained recovery more quickly.

"While the trial did not meet its primary endpoint in reducing time to sustained recovery through day 29, certain patient subgroups did show treatment benefits of Brilacidin for that primary endpoint. For example, patients treated early from onset of symptoms achieved sustained recovery more quickly (Brilacidin 5-dose group vs pooled placebo, p=0.03). To date, only a modicum of success has been demonstrated by any company conducting clinical trials in moderate-to-severe hospitalized cases of COVID-19. A possible reason for this may be owing to frequent changes in the standard of care with patients receiving a cocktail of fluctuating concomitant medications, which complicates the interpretation of the clinical trial data and that of the new drug candidate being evaluated. Clinical observations of COVID-19 patients treated with Brilacidin further lead us to believe that higher and more frequent dosing of Brilacidin may be more appropriate to tackle this complex disease in the hospital setting"

Clearly B needs more study and a human trial of early onset patients. That is what the nasally formula when completed will be tasked to do.

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