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Wednesday, December 07, 2022 12:25:14 PM
https://cbdstconference.com/poster-presenters/
https://cbdstconference.com/wp-content/uploads/2022/09/2022CBDSTconference-abstract-363.pdf
*There is an urgent, unmet need for the development of broad-spectrum intervention strategies that can ideally control the disease manifestations in the host and the spread of disease as a prophylactic countermeasure. Our ongoing studies with brilacidin, a host defense peptide (HDP)-based mimetic, have successfully demonstrated that brilacidin is able to interfere with viral integrity and exert an antiviral effect in vitro against candidate alphaviruses and bunyavirus. Furthermore, early indications support the potential of brilacidin to also act in an anti-inflammatory capacity by reducing inflammatory cytokine expression.
Our observations with brilacidin in the context of acutely infectious viruses support the idea of brilacidin functioning in a broad-spectrum capacity as
a novel antiviral compound.
Research and development efforts are focused on identifying optimal dosing strategies to improve brilacidin in vivo effectiveness in the form of a nasally-delivered countermeasure.*
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