Synaptogenix Inc (SNPX)

[InTheTrenches]

Scanning the journal article, it's hard for me to get a feel how much Wender, et al improved the synthesis of Bryostatin.

A rough guess is that they combined 4 steps into 1 step.

Last I checked I think they were at 29 steps.
(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714505/)

So has Wender now improved the process to 25 steps?

The number of steps gives a rough idea of the economics: the fewer the steps, the less it costs to make.

25 steps is still a very complicated synthesis, but every improvement on the process improves the economics and helps the bottom line.

(As an aside: my understanding of the contract between Wender's group and SNPX does not change, even with improvements in synthesis economics. That is, this improvement will only improve Wender's bottom line; However, this should help to make synthetic Bryostatin more readily available for pre-clinical and clinical trials).