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jondoeuk

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jondoeuk

Re: NY1972 post# 192

Thursday, 11/17/2022 6:31:03 PM

Thursday, November 17, 2022 6:31:03 PM

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Most are going that route, including them. When the S-1 was filed (the IPO has now been abandoned), said they would be using CRISPR (electroporation wasn't going to be used) to knockout genes that encode inhibitory receptors, and could knockout/in genes to improve persistence, with them hinting at B2M/CIITA KO and HLA-E KI. But no additional details, such as editing efficacy were presented.
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