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Thursday, October 06, 2022 3:58:53 PM
The Scripps Research Institute has a portfolio of click-chemistry patents.[55] Licensees include Invitrogen,[56] Allozyne,[57] Aileron,[58] Integrated Diagnostics,[59] and the biotech company baseclick,[60] a BASF spin-off created to sell products made using click chemistry.[61] Moreover, baseclick holds a worldwide exclusive license for the research and diagnostic market for the nucleic acid field. Fluorescent azides and alkynes also produced by such companies as Active Motif Chromeon[62] and Cyandye.[63]
https://en.wikipedia.org/wiki/Click_chemistry
Click Chemistry Conjugations
Utility of this chemistry for site-specific ADCs has been demonstrated [21] and one (Trph-222 from Triphase - licensed from Catalent) has recently entered clinical trial [22].
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7444748/
Bertozzi’s work has spun out many biotech startups, including Lycia Therapeutics, which focuses on degrading previously “undruggable” extracellular protein targets, and Redwood Bioscience, which was later acquired by Catalent.
https://www.statnews.com/2022/10/05/nobel-prize-chemistry-2022/
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