Synaptogenix Inc (SNPX)

[Cyosol]

Any potential effects from withdrawing Memantine use before the trial would also apply to the Bryo group, and yet we see that Bryo patients in both trials have almost the same score at 13 weeks.

Look at the tables and slopes in the latest bryo paper and you'll see it's the #203 placebo results that are statsig, not the #202 one.

I think the real issue is the small sample size which lead to negatively skewed placebo results in the #202 trial and positively skewed placebo results in the #203 trial.

Combine the two groups and you get a 1 point improvement, which is exactly what I would expect from placebo.

A good thing about this latest trial is that they can create a pooled analysis with data from all three trials, bringing the sample size on each side to almost 100.

Whatever the 6 month data may say, we'll at least get a proper look at how both groups perform after 3 months.