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freegriff

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freegriff

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Saturday, 09/24/2022 9:41:40 PM

Saturday, September 24, 2022 9:41:40 PM

Post# of 130502
More MANF China research. in Septic Renal Injury and Colorectal Cancer. Gerald sharing a lot lately.

Conclusion: Mesencephalic astrocyte-derived neurotrophic factor has a certain protective effect on septic renal injury. Exogenous supplement of MANF can effectively alleviate the degree of renal injury after septic renal injury.

https://assets.researchsquare.com/files/rs-1886281/v1/d7812999-0217-4976-92b1-cc8118b50bc7.pdf?c=1663594677

More importantly, exogenous MANF significantly inhibited the migration of colon adenocarcinoma cells HCT116 and SW1116, but did not affect proliferation. Mechanistically, DLC1 reduced the retention of MANF in ER by competing the interaction between MANF and GRP78. Taken together, these data provided new insights into the suppressive effects of DLC1 on CRC, and revealed the potential of MANF in the treatment of CRC.

https://www.frontiersin.org/articles/10.3389/fonc.2022.900166/full
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