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Sunday, 09/18/2022 10:23:57 AM

Sunday, September 18, 2022 10:23:57 AM

Post# of 22
Traditional Chinese Medicine (T.C.M.)

"Interestingly, of the new anticancer drugs developed between 1940 and 2002, approximately 54% were derived from natural products [31]. Another study has determined that of all current pharmaceutical products, about 73%, include ingredients derived from natural products [32]. The therapeutic activity of many traditional medicines are conferred by natural ingredients produced within the plant; consequently, the efficiency of TCM preparations can vary widely and are determined by the genotype, environmental, and growing conditions encountered by each source plant
4.28. Lithospermum erythrorhizon
The dried root of Lithospermum erythrorhizon is indigenous to northeast China and has potent biological activities, including anti-inflammatory, antibacterial, antiangiogenic, and antitumour qualities [261]. Shikonin, a naphthoquinone, is extracted from the root of Lithospermum erythrorhizon and stimulates the activity of caspases, poly-(ADP-ribosyl) polymerase (PARP) and reactive oxygen species (ROS), triggering programmed cell death in cancer cell lines [262]. These characteristics prompted investigation of shikonin as a novel scar remediation therapy. These studies found that shikonin inhibits cell proliferation and collagen production in hypertrophic scar-derived human skin fibroblasts [263]. Arnebin-1, a related naphthoquinone extracted from Lithospermum erythrorhizon, has been reported to synergise with VEGF, resulting in significantly improved wound healing in a rat diabetic model [264]."

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