DNAprint Genomics (DNAG)

[IVRT]

Personalized Medicine and Pharmacogenomics
Doctors and pharmacists have long known that individuals respond differently to the same drug. The reason for this is the underlying genetic variability between individuals. Pharmacogenomics is the study of variable drug response against the backdrop of genetic variability and most properly involves a consideration of complex genetics (a good analogy to this system is the flux-balance model in E. Coli- Schilling et al., 1999). Whereas one person may effectively and safely metabolize a certain drug, another may metabolize the same drug into a dangerous toxin or not metabolize it well at all. By evaluating drug response against genotype, it will be possible to define genetic profiles that are compatible with certain treatment regimens and those which are not. In this way, a patient's response to a drug can be accurately predicted before the drug is prescribed. The idea of using a patient's genotype as a factor in deciding on treatment options is commonly referred to as Personalized Medicine. Though today's drugs are approved and developed based on their performance in a large population of people, medicine of the future will be evaluated and prescribed, tailor made for a particular patient's needs.



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