DNAprint Genomics (DNAG)

[IVRT]

"SNIPdoc" SNP discovery system
The Company maintains a cutting edge high throughput polymorphism-screening laboratory and the SNiPdoc(tm) system is the discovery search engine for this facility. SNiPdoc(tm) is a software system that designs vertical re-sequencing projects, aligns raw DNA sequence data from multiple donors, and uses proprietary statistical routines to find reliable discrepancies between these sequences. The data is formatted and deposited into a relational database system."

The software designs the re-sequencing (sequencing the same gene from multiple donors) of experiments starting with raw human genome data files (NCBI Genbank). The software system begins by defining "important" and "unimportant" regions of a human genome DNA sequence file, then designs primers to flank pertinent regions of the file through formatting these primers for easy oligonucleotide ordering from third party vendors. The software achieves in seconds what it previously took a scientist an hour or more to accomplish during the tedious process of experimental design. After primer design and amphfication, the software allows the company to identify reliable SNPs through a process called multiple sequence alignment and discrepancy validation. The output of the program is a list of SNPs in FASTA format for assay design. Our system has allowed us to create some of the most dense and reliable Gene polymorphism maps anywhere. Whereas publicly available SNPs validate as Polymorphisms at a rate of about 50-60%. Our result is greater than 95%.



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