Synaptogenix Inc (SNPX)

[Cyosol]

Placebo results for the #202 trial aren't statistically significant (p=0.546). Neither are the combined placebo results (p=0.160).

The 2 point placebo increase in the #203 trial however is statistically significant (p=0.014).

The #203 groups are about twice the size of the memantine-free #202 groups which makes their results more reliable than the #202 results.

Compare the two trials to the combined data and you'll see the #203 data is closer to combined data than the #202 data.

I wouldn't be surprised if placebo patients show a 1 to 2 point improvement at 13 weeks in the current trial with bryo patients showing a 4 point improvement. The real question is how things look after 6 months now that both groups are finally big enough and have been adjusted to start from the same baseline.