Thursday, September 01, 2022 9:49:02 PM
As a hypothetical:
What if placebo patients in trial feel worse (withdrawal) for a few weeks after stopping memantine...and they score lower on initial MMSE test than if they continued taking memantine.
About the same time they are receiving first placebo dose, the memantine withdrawal is coming to an end...and the next time they are tested, they feel better and score better on their 2nd MMSE test.
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For this hypothesis to work, memantine withdrawal would have to have less of an effect on the Bryostatin group. Trial imbalance may explain this.
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