Precision BioSciences Inc (DTIL)

[jondoeuk]

The poster is now up https://precisionbiosciences.com/wp-content/uploads/2022/07/Pires-M-Allogeneic-CAR-T-Cells-with-Deoxycytidine-Kinase-Knockdown.-SITC.-2021..pdf

Others, include knockdown of CD319 (reduces or prevents fratricide of CAR+ cells), TGFRB2 (less susceptible to immunosuppression by transforming growth factor beta), CBL-B (less susceptible to suppression of TCR and PD-L1 signaling), CD52 (less susceptible to CD52 antibody induced death) and/or the glucocorticoid receptor (less susceptible to glucocorticoids).

Hopefully, they will start to incorporate these and build a 'library' of additional shRNAs targeting more genes, such as PD-1 https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(21)00498-6 https://ascopubs.org/doi/abs/10.1200/JCO.2022.40.16_suppl.7522 https://ascopubs.org/doi/abs/10.1200/JCO.2022.40.16_suppl.e14514