![](https://investorshub.advfn.com/uicon/756606.png?cb=1653487878)
Monday, August 08, 2022 1:25:34 PM
Healthcare & Pharma
March 20, 2007
Toddler improving on experimental smallpox drug
By Julie Steenhuysen
CHICAGO (Reuters) - An experimental pill appears to be helping a toddler who had a near-fatal skin reaction to his father’s smallpox shot, doctors said on Monday.
The drug, an antiviral made by Siga Technologies called ST-246, worked when more conventional treatment failed, the doctors said.
The 2-year-old, still in critical condition at the University of Chicago’s Comer Children’s Hospital, developed the rare serious reaction called eczema vaccinatum after being with his father, a soldier vaccinated for deployment in Iraq.
“He’s making slow improvement every day. He’s still in the pediatric intensive care unit,” said Dr. John Marcinak, pediatric infectious disease specialist at the hospital.
Marcinak said the rash now consumes 80 percent of the child’s body. “He’s lost a lot of the superficial areas of his skin called the epidermis. There is still a lot of healing that needs to be done,” he said.
The child, from Indiana, was admitted to the hospital on March 3, and the U.S. Centers for Disease Control and Prevention confirmed he was infected with the virus used in the smallpox vaccine.
Smallpox vaccines do not use the smallpox virus, but instead use a related virus called vaccinia that is weakened but can still infect some people.
The child was given an intravenous form of vaccinia immune globulin -- developed in the 1960s to treat complications of smallpox vaccinations. He also received a treatment of the antiviral drug cidofovir, made by Gilead Sciences Inc.
But he was still failing. His mother also had a rash but was not ill and his father reported no adverse reaction.
By then, Marcinak and his team were having daily conference calls with the CDC, health departments, the Department of Defense and the National Institutes of Health. During one, the CDC suggested the hospital try the experimental drug. [ed. Cheers to CDC]
The drug has helped monkeys infected with smallpox, but its effectiveness has not been proven in humans.
Seeing the drug used in an infected patient presents a rare opportunity for Siga. For ethical reasons, the drug can only be tested in healthy volunteers.
“I think we can feel reasonably confident ... that this drug is contributing to the child’s recovery,” Siga Chief Executive Dr. Eric Rose said in a telephone interview.
The child’s case is the first report of eczema vaccinatum since vaccination against smallpox resumed in 2002, CDC pox virus expert Dr. Inger Damon said. She said he may already have had eczema -- which makes patients especially vulnerable to the serious reaction.
[ed. eczema vaccinatum is a potential side efffect of smallpox vaccination although it has occurred followiing vaccination for chicken pox. Interestingly, those who are non-asthmatic and contract chicken pox as children are far less likely to develop eczema & asthma later on, as compared to those who were innoculated against chicken pox.] https://www.foxnews.com/health/chickenpox-may-protect-against-asthma-skin-condition
The smallpox virus once killed 30 percent of its victims, and disfigured many others. A global vaccination campaign eradicated the disease in 1979.
But some samples of smallpox remain in government freezers and experts believe it could be used as a biological weapon. The United States resumed vaccinating some people in 2002, including 40,000 civilian health workers and hundreds of thousands of military personnel.
Rose said the company hopes to have the drug approved for sale by 2009. SIGA shares closed up nearly 14 percent on NASDAQ on Monday, at $5.15 a share.
https://www.reuters.com/article/us-smallpox-vaccine/toddler-improving-on-experimental-smallpox-drug-idUSN1953739120070320
$SIGA
Recent SIGA News
- SIGA Announces Agreement to Sell TPOXX® to ASEAN Member States • GlobeNewswire Inc. • 06/17/2024 08:05:00 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 06/13/2024 08:28:00 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 06/13/2024 08:23:14 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 06/13/2024 08:21:02 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 06/13/2024 08:18:57 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 06/13/2024 08:16:23 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 06/13/2024 08:13:43 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 06/13/2024 08:11:21 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 06/13/2024 08:08:35 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 06/13/2024 08:05:57 PM
- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 05/07/2024 08:58:12 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 05/07/2024 08:06:24 PM
- SIGA Reports Financial Results for Three Months Ended March 31, 2024 • GlobeNewswire Inc. • 05/07/2024 08:05:00 PM
- SIGA Technologies to Host Business Update Call on May 7 Following Release of First-Quarter 2024 Financial Results • GlobeNewswire Inc. • 05/01/2024 09:00:00 PM
- SIGA Amends International Promotion Agreement with Meridian to Enhance International Growth Opportunities of Oral TPOXX® • GlobeNewswire Inc. • 04/01/2024 08:05:00 PM
- SIGA Names Larry Miller General Counsel • GlobeNewswire Inc. • 03/25/2024 11:30:00 AM
- SIGA Reports Financial Results for Three and Twelve Months Ended December 31, 2023 • GlobeNewswire Inc. • 03/12/2024 08:05:00 PM
- SIGA Declares Special Cash Dividend of $0.60 Per Share • GlobeNewswire Inc. • 03/12/2024 11:30:00 AM
- SIGA Technologies to Host Business Update Call on March 12th, 2024 Following Release of Fourth Quarter and Full Year 2023 Financial Results • GlobeNewswire Inc. • 03/05/2024 12:30:00 PM
- Form SC 13G - Statement of acquisition of beneficial ownership by individuals • Edgar (US Regulatory) • 02/01/2024 08:54:12 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 01/30/2024 10:04:04 PM
- Form 3 - Initial statement of beneficial ownership of securities • Edgar (US Regulatory) • 01/30/2024 10:01:59 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 01/22/2024 09:01:28 PM
- SIGA Announces Appointment of Diem Nguyen, Ph.D., MBA, as New Chief Executive Officer • GlobeNewswire Inc. • 01/22/2024 12:30:00 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 01/02/2024 01:49:12 PM
Mass Megawatts Announces $220,500 Debt Cancellation Agreement to Improve Financing and Sales of a New Product to be Announced on July 11 • MMMW • Jun 28, 2024 7:30 AM
VAYK Exited Caribbean Investments for $320,000 Profit • VAYK • Jun 27, 2024 9:00 AM
North Bay Resources Announces Successful Flotation Cell Test at Bishop Gold Mill, Inyo County, California • NBRI • Jun 27, 2024 9:00 AM
Branded Legacy, Inc. and Hemp Emu Announce Strategic Partnership to Enhance CBD Product Manufacturing • BLEG • Jun 27, 2024 8:30 AM
POET Wins "Best Optical AI Solution" in 2024 AI Breakthrough Awards Program • POET • Jun 26, 2024 10:09 AM
HealthLynked Promotes Bill Crupi to Chief Operating Officer • HLYK • Jun 26, 2024 8:00 AM