In addition, the crazy amount of buying power it ties up in your brokerage account is another disincentive to short these highly speculative ones. For example in my Etrade account, shorting 1000 shares of GME at 36 would tie up $144,000 of buying power. That's nuts.
I have seen lots of $1 stocks with strong earnings and solid balance sheets triple, quadruple and more, but I have yet to see one go below zero.