Innovation Pharmaceuticals Inc (IPIX)

[farrell90]

Is the ulcerated oral mucosa that different from an ulcerated sigmoid colon?

The oral mucosa does have less surface area than the sigmoid colon ;so based on surface area brilacidin's absorption should be higher through the colon.

The dosage is in the ulcerative colitis study was 200mg while in the oral mucositis study it was only 3mmg per 5cc.So the absorption should be higher in the UC study

In addition the UC patients were given Brilacidin as a retention enema as opposed to the swish and spit BOM study. The time of contact to the mucosa would be much higher in the UC study.

Yet the UC study showed almost no systemic absorption, nanograms.
Just a reminder 1 billion nanograms are in a gram

" Brilacidin was generally well-tolerated and patients maintained stable normal vital signs during treatment..

Measurements of drug concentrations in plasma continued to show limited systemic absorption of Brilacidin, with all values registering less than 100 ng/mL for all six patients in Cohort A and averaging approximately 200 ng/mL maximum concentrations... "

https://www.globenewswire.com/news-release/2017/03/08/933305/0/en/Cellceutix-Releases-Preliminary-Efficacy-and-Safety-Data-in-Interim-Analysis-of-First-Two-Cohorts-in-Phase-2-Trial-of-Brilacidin-for-the-Induction-of-Remission-of-Mild-to-Moderate-.html

When a company is doing its due diligence to partner with IPIX , do you think they will look at actual numbers ?

Indeed !

GLTA,Farrell