Innovation Pharmaceuticals Inc (IPIX)

[farrell90]

Dr Scott's publication of antifungal research seems to be an extension of the Polymedics HDP development program,

"We have developed a series of non-peptide analogs of the host defense proteins (HDP mimics,
smHDPs) as antimicrobial agents that have distinct advantages over peptides for pharmaceutical use
[16, 17]. The overarching goal of our approach is to recapitulate the biological and structural properties
of HDPs into oligomeric backbones without trying to duplicate the dimensional structures of the
peptides but rather by creating small structurally constrained cationic compounds. These smHDPs have
better pharmacokinetic and tissue distribution properties than peptidic HDPs due to their smaller size
and improved stability; and are less expensive to prepare with the selection of appropriate building
blocks. Furthermore, synthetic chemistry, expanded beyond amino acids, provides considerably more
chemical space to fine-tune structures for enhanced antimicrobial activities and minimized toxicity."

Note reference #16 and 17

JMO,

Farrell

https://pdf.sciencedirectassets.com/271398/1-s2.0-S0960894X20X00254/1-s2.0-S0960894X20308386/am.pdf?X-Amz-Security-Token=IQoJb3JpZ2luX2VjEGkaCXVzLWVhc3QtMSJIMEYCIQC1iZtNywpl%252FQXVFfkGhOHr8wc%252Bsbq%252BedTQfgdsaVI21wIhALTNuyCSKA0ShgjxIb55S3nq9pdrVr%252BVkp7cXaTvAcy%252FKtIECGIQBBoMMDU5MDAzNTQ2ODY1IgwJF%252FKKusKtL%252FN%252BcakqrwRQa3smHiGckr5qIPzBVYYwZmNUuHmG4D23MW4Gvn1luWcDPww81ugv4eABN0g3XMsqrIOC5v7qiXN33s54Hj2HVZTGk5bEImaEupIsQDe9meNFuNwIjww%252FlH7AmdmAxvIdjJMqZgcpUggVTKb7LvK6CVcxc9QMo%252FKmq0Mxi3Dfpnoi1DPnZPCZvwiumf1%252B6MkoBIByXMvpa7OI74%252F7CHsRaQpWu%252BYs5pYQaZR%252Br6LYzR3b85BZ3Efs70L1ZIoGpXZYUb9OsLTlie2qmNmuNjJlp5wIdfsLafdBqbpEr7%252FIfBkTYsqdyyYvDIXSvWO2Jp6FqP4BnoxQg%252B9CcGpcri2ldGDnqNzJ7peAlD93EQPLTUHA4REl455BRpW%252FsEz%252FoYZmVFLw%252FDsTvg6gLjDILUGZFq20UtY7MO32EDvpZQkZ6Fxh6wBOiruLYhE9sQqyB6vPM6FNBu%252F3giacyf5tykXIJGI08qNdRkXUfRVon5YYn%252BRGxVj3oyA8ZC%252F%252FSPQCdFih79hNRz%252B0Uh%252BUVFQwllsbwhO7tmAdGnHfswcdQQReqsKW3Q4lBukxe%252FS9%252FWcWkkHQ2MRZHufGJ%252F1mVwvHCMj6D3M%252Fzpc9nhfJ79BVY%252BjByO0zrHnL9ku80ApKJ2V1ygovl83Cnd2%252FmNccpBBLBeqjMNu8HHmKT9fFtSeP3sQlQFvEpqtQby4NGMGXiSvawS%252BeSwI6Qf6X7efcOcXYQD27ZG0c16uBi6DBHn0vpId9MMDX45QGOqgBgcVZb7vdaJC7chP5sLBhqLwUCqD7sBNX4fdL%252FYvYjsh33GgvBCPNJlA%252BtpDVG5BeYuN6ssdfKPdH2lbkx7Q4oiloyncR%252BOPwSwn7F9O7qImFY5q8dix%252Bmwpk%252BtDvcX74Dsd%252Fjb76xNsRgZ%252FqdwMZyuHvnasHuU4KAMeK5w6yYtlzyaSg7ymK90QUSLlA1oaym0HWzJRipOEeWDpZvafSoJ3b21CurNKa&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Date=20220602T175927Z&X-Amz-SignedHeaders=host&X-Amz-Expires=300&X-Amz-Credential=ASIAQ3PHCVTYWRRMRMEN%252F20220602%252Fus-east-1%252Fs3%252Faws4_request&X-Amz-Signature=922490a70f254a920cd37c57d4e544ca643d9a66fec5df042127a5057f07f70