Suppressing the reproductive axis with GnRH agonists was studied in this context it doesn’t really work. I’m not sure why this would The only good way to protect eggs against effects of chemotherapy is to freeze them and given the high efficacy addressable market for a medication that might move the needle marginally is small You can’t really free sex in the pediatric population but then again this population usually does well after chemotherapy except with high-dose alkylating agents I don’t recall our prior conversation well the presence of Y chromosome material in Women with gonads can result in malignant degeneration and they should be extirpated but I’m not sure testosterone and a trans male would predispose to ovarian cancer and in fact we have trans males that come in and whom we stop testosterone and we help them create embryos and conceive Of course stopping the testosterone is complicated as well in this population for other reasons Excuse typos I’m dictating this
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