Spectrum Pharmaceutecals Inc (SPPI)

[antihama]

Yeah, I just was looking myself and was going to let you know but you beat me to it. Interesting dosing schedule

Participants will receive poziotinib 16 mg, orally, once daily (QD), for 2 weeks or until the onset of Grade ≥2 treatment-related AEs, whichever occurs first, followed by maintenance dose of poziotinib 8 mg, orally, twice daily (BID), up to 2 years or until disease progression, death, intolerable adverse events (AEs), initiation of non-protocol anti-cancer treatment, or other protocol-specified reasons for participant withdrawal from the study.

EDIT- Speculating here on dosing. It's almost like most patients can tolerate 2 weeks of 16mg once daily w/o AEs before they switch to a more tolerable BID schedule; a hybrid dosing schedule best of both worlds kind of way.

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